During an epidemiological study on PSV infections in the fecal samples of piglets with diarrhea in South Korea, three PSV strains were isolated. These Korean PSV strains were characterized using an immunofluorescence assay with a monoclonal antibody specific for a PSV capsid protein, RT-PCR assay with primer pair specific for the PSV VP1 coding region and transmission electron microscopy. Furthermore, bioinformatic techniques were employed to analyze the complete viral genomes of the three newly isolated strains in comparison with the other known PSV strains. Very few synthetic drugs Ponatinib generate an immediate and powerful impact in the biomedical field shortly after their inception. This has been the case particularly within the areas of pre-surgical, surgical, and post-surgical anesthesiology where the need for fast acting, effective pain relievers is a key element in the overall patient care practice. Morphine and Tramadol are two opioid-based compounds that are widely recognized for being the gold standard prescriptions for patients with moderate to severe pain after surgery or with certain disease states. Due to their potency, however, are also well known for their ability to foster chemical dependencies in patients and other users. Though it is often difficult to surpass the established therapeutic records and efficiency profiles by the aforementioned drugs, occasionally new drug candidates are identified that accomplish this seemingly difficult feat. Such is the case for a class of synthetic alkaloids whose birth and swift entrance in the medical field of anesthesiology originated with the synthesis of fentanyl by Paul Janssen in 1960. Since its synthesis, inspired partly by the necessity to improve the potency and bioavailability of the structurally related opiate Demerol, fentanyl analogs with superior pharmacokinetic properties, onset time, and effective dosage have been successfully produced. Currently, a significant array of fentanyl analogs exists spanning a large range of physicochemical properties, which strictly determine their ultimate application. Some of these compounds, along with their potency relative to morphine, are given in Fig. 2. With drugs of this kind, propensity of their users to become physiologically dependent has been reported, and indeed there exist issues involving the use of fentanyl and its analogs. For example, these compounds have been the epicenter of fatal incidents involving overdoses by users who self-administer quantities that are just minimally beyond the carefully prescribed doses for controlling pain in a clinical setting. Additionally, there has been documented military misuse of these compounds for their crowd controlling properties. As a particularly infamous case, the presumed use of gaseous/aerosolized fentanyl derivatives by Russian security forces to incapacitate terrorists during a Moscow theater hostage crisis in 2002 led to the death of 170 people, 127 of them hostages.