Statins, aspirin and beta blockers were more frequently used in CAD patients compared with patients with angiographically normal coronary arteries and reference individuals. This study demonstrates that in patients with symptoms of SAP and either angiographically normal coronary arteries or angiographically diffuse non-obstructive CAD, the risks of cardiovascular hospitalization and CAG are considerably larger than for asymptomatic reference individuals. For the first time, we report event rates and mean accumulated hospitalization times based on recurrent events analyses for a median follow-up of 7.8 years. Accordingly, risk of cardiovascular hospitalization in patients with SAP symptoms and no obstructive CAD at angiography were three- to fourfold higher than in the reference population and the related mean accumulated cardiovascular hospitalization times were 30–100% higher irrespective of cardiac risk factors and cardiac comorbidity. Importantly, risks of cardiovascular hospitalization and accumulated cardiovascular hospitalization times were similar in patients with diffuse non-obstructive CAD and patients with obstructive CAD in models ignoring the first year of follow-up, during which the obstructive-CAD patients were likely to receive invasive treatment. Risk of CAG was two-fold higher in patients with angiographically normal coronary arteries versus reference individuals and likewise, six-fold higher in patients with angiographically diffuse non-obstructive CAD which was only slightly lower than in patients with obstructive CAD. Regarding non-cardiovascular hospitalizations and GP consultations, patients with SAP symptoms generally showed higher event rates compared with the reference population while only minor differences were found between the patient groups. No systematic sex differences were found. Prior studies have reported that angina with a normal CAG is associated with an excellent prognosis. However, small sample sizes and few events might have been an issue in these studies. 
In a large population, we have Enzalutamide recently shown that patients with SAP symptoms and no obstructive CAD at angiography have increased risks of major cardiovascular events compared to an asymptomatic reference population. This has also been highlighted in the WISE study. The present study extends these findings by demonstrating an increased risk of overall cardiovascular hospitalization and repeat CAG in these patients. Eukaryotic microbes typically occupy environments in which fluctuating extrinsic factors such as temperature, light, humidity, and nutrients influence progression through the life cycle. Reactions to these conditions are mediated by transcription factors, protein kinases, G protein-coupled receptors, and other sensors, transducers, and effectors. Many environmental responses have evolved to enhance fitness. For example, sporulation at high humidity is common in fungi that make spores that must imbibe water to germinate. Often sporulation is suppressed in low oxygen environments which may not favor aerial dissemination. In some fungi, solar radiation triggers synthesis of UV-protectants such as carotenoids, or inhibits production of spores that lose viability in light. Other fungi and some slime molds sporulate more intensely in light, perhaps since this signals their presence on the surface of a DAPT growth substrate.