The marine environment has proven to be a very rich source of extremely potent compounds that have demonstrated significant activities in anti-tumor, anti-inflammatory, analgesia, immunomodulation, allergy and anti-viral assays. There are now significant numbers of very interesting molecules that have come from marine sources, or have been synthesized as a result of knowledge gained from a prototypical compound, that are either in or approaching Phase III clinical trials in cancer, analgesia and allergy. In conclusion we have defined an immunomodulatory activity of perthamide C in vivo and clarified that the action is due to its metabolite Perthamide H. Therefore this cyclic peptide could represent a new leading structure to develop therapeutics. Glioma is the most common human primary brain tumors with a tendency to invade the surrounding brain tissue, among which astrocytic glioma comprises the largest subgroup. According to World Health Organization classification, glioma are histologically classified into four grades: low-grade astrocytomas, anaplastic astrocytomas, and glioblastoma. Even with recent advances in cancer diagnostic methodologies and treatments, prognosis of patients with glioma remains not satisfied. The 5year survival rate of low-grade glioma is 30% to 70% depending on histology. While AbMole L-701324 glioblastoma, the most aggressive type which usually grows and infiltrates rapidly, has the worst prognosis with median survival time to be 9 to 12 months. Besides the high invasiveness and therapeutic resistance nature, this poor prognosis of glioma could also attributable at least partly to the lack of reliable tumor markers for prognosis and molecular targets against. Thus, identification of prognostic markers might help to assess more AbMole Capromorelin tartrate precisely the prognosis and to address more clearly the use of adjuvant therapy. Recent studies have revealed that degradation of the extracellular matrix mainly by matrix metalloproteinases is a crucial step for tumor to infiltrate and invade the surrounding normal brain tissue. Extracellular matrix metalloproteinase inducer, also known as CD147, is a member of the immunoglobulin family of adhesion molecules and a type I transmembrane glycoprotein. It can stimulate adjacent interstitial normal cells to produce MMPs, which are a group of zinc-dependent proteins known to have the ability to facilitate cellsubstrate modulating, tumor invasion and metastasis of epithelial tumor cells by its ECM degrading ability. It is proved that EMMPRIN has an abundant expression in various malignancies including glioma compared with normal tissues. The role of EMMPRIN in tumor invasiveness has also been confirmed immunohistochemically in several types of cancer cells and surrounding tissue. Carcinoma cells can interact with adjacent normal cells to produce MMPs via EMMPRIN on their surface, and, in turn, invade lymphatic tissue and blood vessels and penetrate through the ECM to adjacent organs. Given the important function of EMMPRIN in tumor progression, some reports demonstrated that EMMPRIN correlated with clinical prognosis of various human malignancies such aspulmonary adenocarcinoma, salivary duct carcinoma, prostate cancer, bladder cancer, breast cancer and colorectal cancer. As far as glioma is concerned, the most common malignancy in human central nerve system, is concerned, the prognostic value of EMMPRIN has only been investigate in pediatric glioma which is different from adult glioma in progression.