Oxidative Octreotide Acetate stress is a major cause of late complications of DM and may be more pronounced in the pancreas of rats with long and established DM. This may in turn contribute to the high tissue level of OX1R protein observed in the pancreas of rats with long-term diabetes. Colorectal cancer is one of the most common malignant Sodium sulfadiazine diseases worldwide, but the causes of colorectal carcinogenesis and progression are largely unknown. Numerous studies have revealed that genetic and epigenetic changes and oncogenic signaling activation are the major causes of malignant transformation and progression. In recent years, the epigenetic alterations, in particular, the aberrant expression of microRNAs, have been shown critical roles in cancer formation, metastasis, and response to cancer therapy. miRNAs are a novel class of small noncoding RNAs that typically inhibit the translation and stability of messenger RNAs by binding to the 39-untranslated regions of their target mRNAs. miRNAs have 19�C22 nucleotides and are found in all multi-cellular eukaryotic cells. miRNAs have important roles in various biological and pathological processes, such as development, cell proliferation, differentiation, apoptosis, inflammation, stress response and migration. Increasing evidences have suggested that miRNAs are deregulated or upregulated in all types of cancers, acting either as tumor suppressors or as oncogenes, in which the miRNAs play key roles in important aspects of tumorigenesis, such as cancer initiation, differentiation, growth and progression, mainly by interfering with the expression of target genes involved in cell cycle, apoptosis, cell migration and invasion, angiogenesis. Using a miRNA array profile we have found that miRNA were differential expressed in colonic epithelial cells of a colorectal cancer mouse model, the Muc2 gene knockout mice. One of the most changed miRNAs was miRNA-27a. MiR-27a is located at chromosome 19. Its expression levels and biological functions in cancers are controversial.For instance, several studies have reported that miR-27a acts as an oncogene, whose expression is upregulated in breast cancers, colon cancer cell lines, and in hepatocellular adenocarcinoma cells, and that the increased expression of miR-27a is associated with breast cancer progression and poor outcomes.