Biological functional evidence depicted the INSIG2 gene from the very start as a candidate gene for obesity as being involved in the reversed cholesterol transport by an interaction with sterol regulatory element-binding proteins, which are transcription factors that activate the synthesis of cholesterol and fatty acids in the liver and other organs. Even so, studies on the SNP-obesity associations reported inconsistent results. In the present study, we did not obtain statistically significant association between SNP rs7566605 and overweight and obesity. The relationship between rs7566605 with dyslipidemia was also not statistically significant after correcting for multiple testing. A Japanese population study reported that rs7566605 was associated with dyslipidemia in heterogeneous co-dominant genetic model, which known as the first report to identify this associations. So we analyzed the relationship between SNP rs7566605 and dyslipidemia in different heterogeneous models, adjusting for multiple covariates. We found subjects with the CG heterozygote had 1.368-fold increased in OR for dyslipidemia compared to the combination of genotype GG and genotype CC. This result also suggested a heterogeneous co-dominant genetic model in our study. MTHFR gene showed a strong association with hypertension in our cross-sectional analyses, and OR was similar to the result of a previous meta-analysis among Asian population. A common C to T transition at nucleotide 677 and A to C transition at nucleotide 1298 of the gene coding sequence, have been shown to be the most frequent genetic causes for mild hyperhomocysteinemia. High plasma concentration of homocysteine may predispose individuals to atherosclerosis by injuring the vascular endothelium, which might result in hypertension. In the present study, the results suggested that these candidate SNPs were significant genetic contributors to the phenotypes among elderly, indicating that the associations of these SNPs with MetS and metabolic-related traits observed in young population are also able to be observed in elders. Advantages and limitations of our study should be taken into account when interpreting the findings.