In summary, we have reported the identification and isolation of a Eslicarbazepine Acetate subpopulation of human dermal fibroblasts that express the pluripotency marker SSEA3, we have demonstrated an enhanced efficiency of generation of iPSCs from these SSEA3-expressing cells and observed no iPSC generation from the non-SSEA3expressing cells, and we have revealed significantly Denatonium benzoate increased Nanog expression in the SSEA3-expressing fibroblasts, suggesting a possible mechanistic explanation for the differential reprogramming. To our knowledge, this study is the first to identify a pluripotency marker in a heterogeneous population of human dermal fibroblasts, to isolate a subpopulation of cells that have a significantly increased propensity to reprogram to pluripotency and to identify a possible mechanism to explain this differential reprogramming. Ossification of the posterior longitudinal ligament is a kind of abnormal calcification of the posterior longitudinal ligament and the most affected location is at the cervical spine region which may compress the spinal cord and roots, at the same time, lead to various degrees of neurological symptoms from discomfort to severe myelopathy. It is a common disease in China and throughout Asia. Although the mechanism of OPLL remains unclear, genetic and local factors have been proposed and partly confirmed. In the present study, we firstly revaluated the previously result by investigating the phenomenon in a cohort of 36 patients. The statistical analysis was consistent with previous study which demonstrated that the ����TG���� genotype of the SNP rs2273073 and the ����AT���� genotype of the SNP rs235768 were associated with the susceptibility of OPLL again. In order to study the probably mechanism of this relationship, ligament tissues from OPLL patients showed enchondral ossification by histological examination and the expression of BMP2 were significantly higher by immunohistochemistry and Western blotting analysis compared with the non-OPLL patients. These results demonstrated that BMP2 was critical for endochondral bone development in OPLL. Next, we established the difference of sensibility to mechanical stretch between different BMP2 gene variants.