Despite the wide diversity in reproductive strategies, there are characteristic morphological and physiological changes that occur as the oocytes grow and mature. In general, active nuclear transcription and DNA recombination drives meiotic divisions of oogonia during primary growth phases of development. The primary oocyte stage is characterized by the formation of the Mepiroxol follicle including the granulosa cells, which surround the oocyte, the basal lamina, produced by the granulosa layer and the theca cells including blood vessels. Also, one can 
discern the beginning of formation of oocyte microvilli, extending towards the granulosa layer, followed by extensions of microvilli from the granulosa layer towards the oocyte. During this phase, meiosis is arrested at the diplotene stage of prophase I and the oocyte is characterized by intensive mRNA transcription. Towards the end of this phase, cortical alveoli are visible in the cytoplasm of the growing oocytes and the network of microvilli extending both from the oocyte and the granulosa towards each other is well formed and there is a distinguishable outer zona radiata layer around the oocyte. Primary oocytes progress into secondary growth phase and are characterized by active uptake of nutritional resources including the egg yolk precursor protein vitellogenin and lipids and active deposition of the zona radiata interna. The significant increase in the rate of Vtg uptake is also associated with a marked increase in cell size. In early stages of oocyte maturation, yolk globules become distinct and visible, eventually fusing into a large, single globular yolk formation that precedes germinal vesicle breakdown and final oocyte maturation and ovulation. In some cases, atresia may occur in which the oocyte is reabsorbed prior to ovulation. Atresia can occur at any stage of oocyte development and this process can be influenced by environmental factors and the individual’s physiological status. Transcriptomics-based Folinic acid calcium salt pentahydrate studies in the teleostean ovary have provided valuable insight into the molecular events leading to ovulation. In many cases, the transcriptional response can be associated with the physiological and morphological changes that are occurring in the ovary. Gene expression studies have been performed in teleost fishes with different reproductive strategies, including both fractional and seasonal spawners. Largemouth bass are widely distributed throughout the southern continental USA. LMB have significant economic value because they are highly prized in the sport-fishing industry, in addition to being ecologically important as apex predators in their freshwater environments. LMB are semisynchronous reproducers and many populations in central Florida typically spawn during mid to late spring when water temperatures are approximately 75uF. Floridian LMB sampled in mid-late spring have higher gonadosomatic indices when compared to individuals sampled in other seasons, and in the summer months Florida LMB are sexually recrudescent, exhibiting little ovarian development. The present study uses a transcriptomics-based approach and bioinformatics to characterize the molecular events in the LMB ovary throughout a complete breeding season. Microarray analysis was conducted for eight distinct histological stages in wild female LMB that included ovulated eggs and ovaries that contained atretic oocytes.