Three methods, including soil amendment, seed priming and foliar application, used in Zn fertilizations, have been extensively reviewed. In recent years, a considerable progress has been made on the impact of foliar Zn fertilization on biofortification of Zn in rice grain, since it has the advantages of low application rates and avoiding Zn losses through soil fixation. Furthermore, foliar applied Zn caused greater increases in brown rice Zn concentration than soil application. There is evidence in literature demonstrating that foliar applied Zn can be absorbed by leaf epidermis, and remobilized and transferred into the rice grains through the phloem and several members of the Zn-regulated transporters regulate this process. In most of those literatures, the reported data are mostly based on brown rice. As polished rice is the main consumed portion by human, rare information was found on Zn concentration in polished rice after foliar Zn fertilizations. Moreover, time of foliar application and the different forms of foliar Zn fertilizers may differentially influence grain Zn concentration. In recent past, several AZ 960 studies have been conducted to adjust time of foliar Zn application in cereal crops. It is now well established that foliar Zn application after flowering stage more distinctly increase the grain Zn concentration. On the other hand, different Zn fertilizers such as inorganic and organic Zn salts play a fundamental role in the way in nutrient transport from leave to the grain. Unfortunately, studies evaluating the effectiveness of foliar application of different Zn forms on rice grain Zn accumulation are still rare. The metabolizable Zn from biofortified crop grain not only depends on net Zn concentration, but also a large extent on the bioavailability of Zn. Zinc bioavailability defined as the proportion of the total amount of Zn that is potentially absorbable in a metabolically active form. Phytic acid, the naturally occurring anti-nutrient presents in the seed, reduces the bioavailability of Zn, because of its ability to form complex with Zn, and inhibits Zn solubility, digestibility and absorption in human body. Although, it is assume that foliar Zn fertilization improved Zn bioavailability, but till now there are rare studies on the Zn bioavailability of rice grain deserved from different forms of foliar Zn application. Hence, an in vivo approach to assess the potential benefits of different forms of foliar Zn application on grain Zn bioavailability is required. Posttranscriptional regulation, an important process inthe control of gene expression, starts with interactions of RNA-binding proteins with cis-acting elements in the regulated transcripts. HuR is among the most prominent RNA binding proteins, which modulates mRNA stability and translation, and consequently regulates cell proliferation, angiogenesis, apoptosis, and stress response. HuR, a member of the Hu family, is ubiquitously expressed and related to Drosophila embryonic lethal abnormal vision protein. The other three members of the Hu family, HuB/HelN1, HuC and HuD, are primarily expressed in the neuronal tissues. HuR contains three RNA-recognition motifs through which it binds to AUor U-rich sequences in 39-untranslated regions of target mRNAs. HuR is predominantly localized in the nucleus under non-stress conditions. Upon stimulation, such as heat shock, where it regulates mRNA stability and/or translation. The export of HuR is mediated at least by two pathways, transporting by transportins 1 and 2, or by pp32 and APRIL in CRM1-dependent manner.